Harmful Effects of NSAIDs

NSAID's - not the best choice for your healthFor years, the drugs used to control the inflammatory response, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), have been immunosuppressive, and could cause dangerous side effects.  The benefits and long-term risks associated with the use of NSAIDs need to be weighed very carefully.

NSAIDs, which include aspirin, ibuprofen, salicylates, and naproxen, are among the most commonly prescribed medications for inflammation resulting from rheumatoid arthritis, joint conditions, osteoarthritis, gouty arthritis, joint and muscle discomfort associated with systemic lupus erythematosus, and other musculoskeletal disorders.  In some cases, this overeliance on NSAIDs has proved deadly.  Annually, 76,000 people are hospitalized from NSAID-induced gastrointestinal complications.  The American Medical Association estimates that from 50-80 percent of those hospitalized for gastrointestinal bleeding are taking some form of NSAIDs.  At this stage in the medication-induced bleeding, there is a 10% chance of fatality.

"We see too many patients suffering the effects of NSAIDs"Virtually all NSAIDs inhibit prostaglandin El, a local hormone responsible for gastric mucosal cytoprotection.  This results in the inhibition of gastric prostaglandin E, a hormone which protects the lining of the stomach from acid.  After prolonged and frequent ingestion of NSAIDs, the stomach remains defenseless and at increased susceptibility to ulcers.  If an ulcer erodes into a blood vessel, bleeding results.  An ulcer can destroy part of the stomach and duodenal walls, leaving a gap that requires immediate surgery.

NSAIDs lethal effects result from the inhibition of the biosynthesis of prostaglandins. NSAIDs block cyclo-oxygenase, the enzyme responsible for catalyzing the reactions of arachidonic acid to endoperoxide compounds.

Adverse reactions that are more serious, such as blood disorders, kidney damage, and cardiovascular effects, have also been noted.  

NSAIDs can have toxic effects on cartilage, contributing to joint destruction.Besides damaging the gastrointestinal tract, NSAIDs also interfere with and suppress bone repair and remodeling.  One paper presented data obtained over a 12-year period, and outlined the effects of NSAIDs on the matrix synthesis and turnover in 650 arthritic and 180 non-arthritic human cartilages.  The study showed that one category of NSAIDs that includes Naproxen, ibuprofen, indomethacin, and nimezulide, significantly inhibited matrix synthesis and had toxic effects on cartilage metabolism.  Thus, it appears that the drugs many patients take to relieve their arthritic pains actually contributes to further destruction of their joints!

Additionally, NSAIDs have been shown to interfere with patients' sleep patterns. One study at the sleep laboratory at Bowling Green State University in Ohio demonstrated that aspirin and ibuprofen, in comparison to a placebo, increased the number of awakenings and the percentage of time spent awake.  The drugs also decreased sleep efficiency, and delayed the onset of the deeper stages of sleep.

NSAIDs have also induced adverse psychiatric reactions.  Five psychiatric outpatients - two with major depressive disorders, one with a bipolar disorder, one with a schizophrenic disorder, and one with an anxiety disorder - were treated with NSAIDs due to rheumatoid arthritis, osteoarthritis, or other painful neuromuscular conditions.  All five patients developed moderate to severe depression.  Three patients became paranoid, and four either attempted or considered suicide.  These psychiatric symptoms disappeared once the patients stopped taking NSAIDs.  When the patients re-started the drugs, the symptoms returned.

Too often, the medical community prescribe NSAID's on a "musical chair" basis - trying one after another
Due to the detrimental effects of NSAIDs on the body, most physicians resort to a game of "NSAID musical-chairs," taking a patient off one NSAID as soon as side effects become evident or the drug stops working, then treating the patient with another of the 10 most widely prescribed propionic acid-derived NSAIDs.


Your health, and the health of those you love, is at stake.
Considering all the above, doesn't an all-natural, safe alternative
to these drugs simply make good sense?